Proteostasis Therapeutics, Inc. is the first company dedicated to the discovery of new therapeutics based upon understanding the body’s natural Proteostasis Network. Advances in our ability to characterize and pharmacologically control the Proteostasis Network create new opportunities for ameliorating diseases in a wide number of therapeutic areas. Regulation of the Proteostasis Network is a new approach to drug discovery that will provide the kind of foundational understanding that we have witnessed with other breakthrough treatment paradigms, such as with kinases and G-protein coupled receptors.