The solutions available today for sponsors to manage their imaging clinical trials are expensive, error prone, inefficient, and non transparent. They are typically based on picture archiving and communications systems (PACs) or research information systems (RIS), which were originally developed for the medical/ hospital segments and poorly reverse engineered to meet the requirements of the clinical trial segment which are substantially different. In addition, most of the traditional options available to sponsors rely more on manpower rather than technology. This has resulted in solutions which provide very little control to the sponsors during the trial resulting in avoidable budget overuns, delays and risks to the trials.