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Lisa Massmanian Email
VP and Head Clinical Operations . Cabaletta Bio
Philadelphia, PA
Locationl**************@cabalettabio.com
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About
Cabaletta Bio is focused on the discovery and development of T cell therapies for B cell-mediated autoimmune diseases. Cabalettaￃﾢ￢ﾂﾬ￢ﾄﾢs therapeutic platform produces highly selective autologous Chimeric AutoAntibody Receptor (CAAR) T cells that are designed to precisely bind and destroy only specific autoantibody-producing B cells while sparing normal antibody-producing B cells, which are essential for human health. The platform is based on the revolutionary Chimeric Antigen Receptor (CAR) T cell technology developed at the University of Pennsylvania that resulted in one of the first commercially-available CAR T cell products for the treatment of B cell malignancies. Cabaletta has an exclusive global licensing agreement and multiple sponsored research agreements with the University of Pennsylvania to develop the CAAR T technology to treat B cell-mediated autoimmune diseases. The Companyￃﾢ￢ﾂﾬ￢ﾄﾢs lead therapeutic program is a potential treatment for a prototypical B cell-mediated autoimmune disease, mucosal pemphigus vulgaris (mPV), which is a rare skin disorder that causes painful blisters and sores on mucous membranes leading to severe and sometimes debilitating and life-altering effects. The IND for the lead product candidate, DSG3-CAART, was accepted in September 2019 and was granted Fast Track Designation by the FDA in May 2020. The Phase 1 clinical trial for DSG3-CAART is now open for recruitment.Cabaletta Bio Address
2929 Arch StPhiladelphia, PA
United States