Scarab Genomics, LLC was established in 2002 to commercialize the Clean Genome®
Multiple Deletion Series (MDS) E. colà resulting from Dr. Fred Blattner’s research at the
University of Wisconsin, Madison. Scarab Genomics has licensed the patented reduced
genome technology from Wisconsin Alumni Research Foundation on an exclusive,
worldwide basis.
Clean Genome® E. colà was bioengineered by deleting over 15% of the K-12 genome.
Using synthetic biology methods, a series of precise deletions were made, including
the elimination of non-essential genes, recombinogenic and mobile DNA, and cryptic
virulent genes. Genome reduction optimizes these E. colà strains for production, providing
enhanced genetic stability and improved metabolic efficiency. Clean Genome® E. colà are
the strains of choice for a wide spectrum of applications ranging from routine cloning to
large scale production of biopharmaceuticals.